Population genomics in a disease targeted primary cell model
نویسندگان
چکیده
منابع مشابه
Population genomics in a disease targeted primary cell model.
The common genetic variants associated with complex traits typically lie in noncoding DNA and may alter gene regulation in a cell type-specific manner. Consequently, the choice of tissue or cell model in the dissection of disease associations is important. We carried out an expression quantitative trait loci (eQTL) study of primary human osteoblasts (HOb) derived from 95 unrelated donors of Swe...
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Genetic epidemiology studies have established that the natural variation of gene expression profiles is heritable and has genetic bases. A number of proximal and remote DNA variations, known as expression quantitative trait loci (eQTLs), that are associated with the expression phenotypes have been identified, first in Epstein-Barr virus-transformed lymphoblastoid cell lines and later expanded t...
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ژورنال
عنوان ژورنال: Genome Research
سال: 2009
ISSN: 1088-9051
DOI: 10.1101/gr.095224.109